288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1H-Pyrazole
To a solution of Compound 1 (10 g, 72.5 mmol) in dry DMF (100 mL) were added pyrazole (10 g, 145 mmol), K2C03 (20 g, 145 mmol) and 18-crown-6 (2 g). The resulting solution was stirred at 130 C for 4 hours. After cooling to RT, the residue was treated with water and extracted with EA. The organic extracts were washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated to give a crude oil. The crude product was purified by recrystallization to afford Compound 2 (3.5 g, 26 %). 1HNMR (CDC13, 300 MHz) oe: 2.6-2.7 (s, 3 H), 6.4-6.5 (s, 1 H), 7.7-7.9 (m, 3 H), 8.0-8.2 (m, 3 H).
The synthetic route of 288-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; KOYUNCU, Emre; SUN, Qun; CHIANG, Lillian; (98 pag.)WO2016/77232; (2016); A2;,
Pyrazole – Wikipedia,
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