Adding a certain compound to certain chemical reactions, such as: 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181585-93-3, SDS of cas: 181585-93-3
Methyl 3-nitro-1H-pyrazole-5-carboxylate (1.71 g,10 mM) was dissolved in methanol (40 mL), and 10% Pd/C (0.26 g) was added. Hydrogenation wascarried out in a Paar apparatus under 5 bar. After 24 h, the catalyst was filtered o and washedby methanol. The solvent was evaporated by reduced pressure, and the residue was crystallizedfrom ethanol (10 mL). Yield: 1.14 g, 81%. Melting point by DSC: 116 and 142 C (Figure S23). TLC:CHCl3/MeOH/AcOH (90:8:2) Rf = 0.43. Elemental analysis for C5H7N3O2: calculated C, 42.55%; H,4.96%; N, 29.79%; found: C, 42.70%; H, 5.00%; N, 29.71%. 1H NMR (400MHz, DMSO-d6) delta(ppm):tautomer T5; 12.16 (1H, s, N-HPz), 5.68 (1H, s, C-HPz), 5.19 (2H, s, NH2), 3.75 (3H, s, CH3), tautomerT3; 12.60 (1H, s, N-HPz), 5.92 (1H, s, C-HPz), 4.81 (2H, s, NH2), 3.75 (3H, s, CH3) (Figure S15). 13CNMR (400 MHz, DMSO-d6)delta (ppm): tautomer T5; 159.65 (C=O), 148.85 (C-NH2), 132.54 (C-C=O),89.04 (C4-H), tautomer T3; 162.87 (C=O), 156.20 (C-NH2), 142.35 (C-C=O), 94.27 (C4-H).
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Reference:
Article; Kusakiewicz-Dawid, Anna; Porada, Monika; Dziuk, B?azej; Siod?ak, Dawid; Molecules; vol. 24; 14; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics