Adding a certain compound to certain chemical reactions, such as: 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37622-90-5, Recommanded Product: Ethyl 4-pyrazolecarboxylate
A mixture of 1H-pyrazole-4-carboxylic acid ethyl ester (5.0 g, 35.7 mmol), PIVIBC1 (6.2 g, 39.3 mmol) and K2C03 (7.4 g, 53.6 mmol) in MeCN(100 mL) was refluxed for 16 hrs. Excessive K2C03 was removed by filtration and the filtrate was concentrated to dryness. The residue was purified by silica gel column (PE/EA = 5/1) to give 1-(4-methoxy-benzyl)-1H-pyrazole- 4-carboxylic acid ethyl ester (9.5 g, yield: >100%) as a colorless oil.
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Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics