In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89717-64-6, name is 4-Bromo-3-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Bromo-3-nitro-1H-pyrazole
To a 50 ml reaction flask by adding 3-nitro-4-bromo -1H-pyrazole (8.9mmol), 2,5-difluorobenzylbromide (9.7mmol), potassium carbonate (26.7mmol) and a catalytic amount tetrabutyl ammonium bromide, adding 20mLN, N-dimethyl formamide, stirring at room temperature 1h. After the reaction is complete the reaction liquid 10 ml water, precipitating a large amount of white solid, filtering, the solid dried to obtain the yellow solid is the product. (Yield 92%)
The synthetic route of 89717-64-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan University; Yang, Shengyong; Wei, Yuquan; (24 pag.)CN105669558; (2016); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics