Electric Literature of 175277-11-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175277-11-9, name is 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one (0.200 g, 0.82 mmol) and 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid (0.164 g, 0.96 mmol), and pyridine (0.32 mL, 4 mmol) in acetonitrile (5 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.13 m L, 2.04 mmol). The sealed tube was heated to 100 C. for 16 h and the precipitation formed. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile/water to give 3-(tert-butyl)-1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-5-carboxamide (0.216 g, 65%). 1H NMR (400 MHz, DMSO-d): delta 12.60 (bs, 1H), 10.19 (s, 1H), 7.75 (m, 1H), 7.71 (dd, 1H, J=8.4, 2.0 Hz), 7.53 (s, 1H), 7.33 (s, 1H), 6.91 (d, 1H, J=8.0 Hz), 4.09 (s, 3H), 2.94 (t, 2H, J=7.2 Hz), 2.48 (partial masked under d-DMSO, m, 2H), 1.27 (s, 9H). MS (ESI): Calcd. for C21H23N5O2S: 409, found 410 (M+1)+.
The synthetic route of 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nantbio, Inc.; Tao, Chunlin; Nallan, Laxman; Ho, David G.; Wang, Qinwei; Weingarten, Paul; Juncker-Jensen, Anna B.; (121 pag.)US2018/201610; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics