Reference of 92933-47-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 92933-47-6 as follows.
To an ice-bath and stirred solution of fuming HNO3 (700.00 mg, 11.11 mmol, 0.5 mL, 1.71 eq) and fuming H2SO4 (1.88 g, 18.76 mmol, 1.02 mL, 98% purity, 2.89 eq) was added 3-isopropyl- lH-pyrazole-5-carboxylic acid (1 g, 6.49 mmol, 1 eq) in portionwise at 0 C over 5 min. After addition, the mixture was stirred at this temperature for 1 h then at 100 C for 6 h. LC-MS showed the starting material was consumed completely and one main peak with desired MS was detected. The mixture was poured into ice-water (30 g), the white precipitate was filtered and dried to yield 3-isopropyl-4-nitro-1H-pyrazole-5-carboxylic acid (700 mg, 3.20 mmol, 49.36% yield, 91.1% purity) as a white solid. MR (400 MHz, CD3OD) delta ppm 3.56 (spt, J = 7.0 Hz, 1H), 1.35 (d, J = 7.1Hz, 6H); ES-LCMS m/z 200.1 [M+H].
According to the analysis of related databases, 92933-47-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KYN THERAPEUTICS; CASTRO, Alfredo C.; EVANS, Catherine Anne; (632 pag.)WO2018/195397; (2018); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics