In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 155377-19-8 as follows. Formula: C7H7F3N2O2
A. N-(ADAMANTAN- 1 -YLMETHYL)- 1 -(4-AMINO-5-FLUOROPYRIMIDIN-2-YL)-3 – (TRIFLUOROMETHYL)- lH-PYRAZOLE-4-CARBOXAMIDE (COMPOUND 1); Step 1. Trifluoromethyl-lH-pyrazole-4-carboxylic acid; NaOH (3 mL, 10 N) is added to a solution of 3-trifluoromethyl-lH-pyrazole-4- carboxylic acid ethyl ester (5.0 g, 24 mmol) in MeOH (25 mL) at RT. The mixture is heated to 40 C for 3 h. The solvent is removed to dryness. H2O is added. The solution is acidified with 2N HCl to pH = 6 to afford the title compound as an off-white solid.
According to the analysis of related databases, 155377-19-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROGEN CORPORATION; WO2009/12482; (2009); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics