Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C5H6N2O
Step 2:, I-methyl -IH-pyrazole-4-carbaldehyde oxirne VA mixture Of the combined organic layer having l-methyl-IH-pyrazole-4-carbaldehyde and ethyl acetate obtained from step I and hydroxylamine hydrochloride (63.48gm, 0.9135 moles) was refluxed at 70-80C for 2-4 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 0-5C, to this added DM water (100 ml) and 25% aqueous ammonia solution (100 ml) at 0-5C. The reaction mixture was stirred for 10 mm at 20-30C. The organic layer was separated and aqueous layer was extracted withethyl acetate (250 ml). The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (500 ml). Stirred for 10 mm and separated the final aqueouslayr and organic layer. The organic layer was evaporated to obtain the l-methyl-lHpyrazole-4-carbaldehyde oxime.Drywt V : 60gmYield :1.2w/w(79%)HPLC purity : 99.78%
The synthetic route of 25016-11-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RALLIS INDIA LIMITED; PALIMKAR, Sanjay Sambhajirao; PAWAR, Jivan Dhanraj; SANKAR, B; KADAM, Subhash Rajaram; HINDUPUR, Rama Mohan; PRABHU, Venkatesh M; PATI, Hari Narayan; SUPHALA, Vadiraj Gopinath; MANE, Avinash Sheshrao; WO2014/2110; (2014); A1;,
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