Reference of 132712-71-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
SBA-Pr-NH2 (0.02 g) was activated into a round-bottomed flask containing a magnetic stirrer at 100 C for removal of the adsorbed water. The mixture of ninhydrin (1 mmol, 0.178 g), 1,2-aryl-diamines (1 mmol), and SBA-Pr-NH2 in 5 ml ethanol was heated and stirred at 60 C to form indenoquinoxaline A; then, after about 5 min, malono derivatives (1 mmol) and alpha-methylencarbonyl compounds (1 mmol)were added to the mixture of reaction for the synthesis of spiro[indeno[2,1-b]quinoxaline derivatives under reflux condition using MW irradiation (400 W, 80 C). Completion of the reaction was monitored by TLC. After that, obtainedprecipitate was cooled to room temperature and extractedfrom the solvent. Subsequently, the precipitate was dissolvedin minimum volume of hot acetone and the unsolvable SBA-Pr-NH2 catalyst was removed by filtration. The residue was purified by recrystallization from ethanol. The new compound was characterized by mass, IR, and NMR spectroscopy techniques. The melting points of the products were compared with those reported in the literature.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1H-pyrazol-5-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ahmadi, Tahereh; Mohammadi Ziarani, Ghodsi; Bahar, Shahriyar; Badiei, Alireza; Journal of the Iranian Chemical Society; vol. 15; 5; (2018); p. 1153 – 1161;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics