Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C10H15N3O2
4,6-Dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester(0.30 g, 1.43 mmol) was dissolved in tetrahydrofuran (10 mL).Nitrogen protection, sodium hydride (0.11 g, 2.85 mmol, 60%) was added at 0 C.Slowly rise to room temperature for 1 hour, then cool to 0 C,Add 5-methylthiophene-2-sulfonyl chloride (0.39 g, 1.99 mmol),The reaction was carried out for 6 hours at room temperature. The reaction was quenched by adding water (10 mL) at 0 C.Extracted with ethyl acetate (20 mL×3).The combined organic phases were washed with a saturated sodium chloride solution (10 mL) and dried over anhydrous sodium sulfate, concentrated by suction filtration, and the residue was subjected to silica gel column chromatography[ethyl acetate / petroleum ether (v / v) = 1 / 9] purified,The title compound was obtained (0.40 g, yield 76%).It is a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
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