Adding a certain compound to certain chemical reactions, such as: 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23170-45-8, Formula: C6H8N2O2
N2 protection,Methyl-1H-pyrazole-4-carboxylate (0.14 g, 1.0 mmol), CuI (19.1 mg, 0.1 mmol), K2CO3 (0.29 g, 2.1 mmol)III1 (0.318 g, 1.2 mmol),(E) -N, N’-dimethyl-1,2-cyclohexyl diamine (28.5 mg, 0.2 mmol) and DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3)Saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 6: 1),0.15 g of methyl 4- (3′-cyano-4′-piperidine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV1) as a yellow solid in a yield of 46.2%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; South China University of Technology; Zhang Lei; Wu Fangping; Li Jing; Zou Yake; (15 pag.)CN106632245; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics