Electric Literature of 37687-24-4, The chemical industry reduces the impact on the environment during synthesis 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, I believe this compound will play a more active role in future production and life.
[00590] 7rt-Butyl-[(2R)-2-hydroxypropyl]carbamate (6.46 g, 36.86 mmol) was added to a stirred solution of diethyl-3,5-pyrazoledicarboxylate (3.9 g, 18.43 mmol), triphenylphosphine (8.7 g, 33.18 mmol) and DTBAD (7.64 g, 33.18 mmol) in THF (150 mL) at 0 C. The mixture was stirred at 80 C for 16 h. The solvent was then evaporated in vacuo, the crude product purified first by open column chromatography (silica; DCM 100%) and then by flash column chromatography (silica, DCM in Heptane 0/100 to 100/0 and then EtOAc in DCM 0/100 to 50/50). The desired fractions were collected and the solvents evaporated in vacuo to yield diethyl-l- {(l*5)-2-[(tert-butoxycarbonyl)amino]-l- methylethyl}-lH-pyrazole-3,5-dicarboxylate as a white (7.6 g, 20% purity, 22 % yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 3,5-pyrazoledicarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; STAUFFER, Shaun, R.; BARTOLOME-NEBREDA, Jose Manuel; CONDE-CEIDE, Susana; MACDONALD, Gregor, James; TONG, Han Min; ALCAZAR-VACA, Manuel Jesus; ANDRES-GIL, Jose Ignacio; WO2013/192350; (2013); A1;,
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