Application of 28466-26-4, The chemical industry reduces the impact on the environment during synthesis 28466-26-4, name is 4-Aminopyrazole, I believe this compound will play a more active role in future production and life.
To a solution of 1 H-pyrazol-4-amine (1 g, 95% purity, 11 .4 mmol) in acetonitrile (57 mL) were added (bromomethyl)cyclopropane (1.65 ml, 17.1 mmol, GAS-RN 7051-34-5),powdered potassium carbonate (3.95 g, 28.6 mmol), and triethylamine (2.39 mL,17.1 mmol). The mixture was heated to 900 for 4h and stirred at room temperatureovernight. For work-up, it was filtered, and the solid was rinsed with ethyl acetate.Goncentration of the filtrate in vacuo followed by flash chromatography led to N(cyclopropylmethyl)-1 H-pyrazol-4-amine (416 mg, 24% yield, 90% purity).LG-MS (Method B): Rt = 0.54 mm; MS (ESIpos): m/z = 138 (M÷H)1HNMR (400MHz, DMSO-d6) oe [ppm]: 0.16 (m, 2H), 0.42 (m, 2H), 0.99 (m, 1H), 2.68 (m,2H), 4.23 (m, 1H), 7.03 (5, 2H), 12.01 (5, 1H).As additional fraction, N, N-bis(cyclopropylmethyl)- 1 H-pyrazol-4-am me was isolated(657 mg, 27% yield, 90% purity).LG-MS (Method B): Rt = 0.97 mm; MS (ESIpos): m/z = 192 (M÷H)1HNMR (400MHz, DMSO-d6) oe [ppm]: 0.06 (m, 4H), 0.33 (m, 4H), 0.84 (m, 2H), 2.82 (d,4H), 7.07 (5, 2H), 12.07 (5, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Aminopyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; WERNER, Stefan; CLEVE, Arwed; (139 pag.)WO2018/210729; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics