Adding a certain compound to certain chemical reactions, such as: 25700-12-3, name is 3-(1H-Pyrazol-1-yl)pyridine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25700-12-3, HPLC of Formula: C8H7N3
To a solution of 3-(1H-pyrazol-1-yl)pyridine (5 g, 34.4 mmol) in acetonitrile (68.9 ml) was added N-bromosuccinimide (7.97 g, 44.8 mmol). The reaction mixture was stirred at ambient temperature for 3H. The reaction mixture was diluted with EtOAc and washed with H2O, the organics were dried with MgSO4, filtered and concentrated in vacuo. The residue was purified by column chromatography eluting with 0-60% EtOAc in hexanes to afford 3-(4-bromo-1H-pyrazol-1-yl)pyridine as a tan solid (6.99 g, 91%): mp 126-127 C.; 1H NMR (400 MHz, acetone-d6) delta 9.12 (d, J=2.5 Hz, 1H), 8.64 (d, J=0.5 Hz, 1H), 8.58 (dd, J=4.7, 1.4 Hz, 1H), 8.23 (ddd, J=8.3, 2.7, 1.4 Hz, 1H), 7.85 (s, 1H), 7.56 (ddd, J=8.3, 4.7, 0.7 Hz, 1H); EIMS m/z 223.
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Reference:
Patent; DOW AGROSCIENCES LLC; Lowe, Christian T.; Trullinger, Tony K.; Hunter, Ricky; US2012/220453; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics