Application of 2075-46-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2075-46-9, name is 4-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of 4-nitro-1H-pyrazole (1.13 g, 10 mmol) in DMF (20 ml) was added K2CO3 (1.38 g, 10 mmol) and 2-Bromoethanol(1.50 g, 12 mmol). Then the mixture was stirred at 60 C for 12 h. DMF was removed at reduced pressure and add water (100 ml), extractedwith ethyl acetate (3×100 ml), dried with Na2SO4 and evaporated to give compound 2a as a white solid.
The synthetic route of 4-Nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ding, Huai-Wei; Wang, Shu; Qin, Xiao-Chun; Wang, Jian; Song, Hong-Rui; Zhao, Qing-Chun; Song, Shao-Jiang; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2729 – 2740;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics