Related Products of 51516-67-7,Some common heterocyclic compound, 51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.
Reference:
Article; Cao, Hai-Qun; Chu, Zhi-Wen; Liu, Hao; Lv, Xian-Hai; Xia, Dong-Guo; Bioorganic Chemistry; vol. 99; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics