Electric Literature of 5775-86-0, The chemical industry reduces the impact on the environment during synthesis 5775-86-0, name is 4-Bromo-1,5-dimethylpyrazole, I believe this compound will play a more active role in future production and life.
To compound 264.4(5.Og, l6mmol, 1.Oeq) and 4- bromo-1,5-dimethyl-1H-pyrazole (2.74g, l4mmol, 0.84eq) in 1,4-dioxane (4OmL), potassium carbonate (6.96g, 48mmol, 3.Oeq) was added. Argon gas was purged through the reaction for 10- 1 5mm. Then, [1,1 ?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)] complex with CH2C12 (0.41g, 0.48mmol, 0.O3eq) was added. Reaction mixture was stirred at 100-110 C for 3h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and evaporated under vacuum to obtain 264.5 (1.5g, 33.6%). MS(ES): m/z 266.37 [M+H]t
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1,5-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics