Related Products of 127107-23-7,Some common heterocyclic compound, 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, molecular formula is C4H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To 8a (0.25 g, 0.95 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloridesalt (0.14 g, 1.1 mmol) in n-butanol (5 mL) was added trifluoroaceticacid (0.27 g, 2.4 mmol), and the mixture was stirredovernight at 120 C. The mixture was then concentrated, neutralizedwith ammonia in methanol, and purified by column chromatography(dichloromethane: methanol=60:1) to yield 0.26 g (86.7%) of 9a as apale-yellow solid. MS (ESI) m/z 326 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-4-amine hydrochloride, its application will become more common.
Reference:
Article; Yu, Ru-Nan; Chen, Cheng-Juan; Shu, Lei; Yin, Yuan; Wang, Zhi-Jian; Zhang, Tian-Tai; Zhang, Da-Yong; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1646 – 1657;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics