Application of 3398-16-1, A common heterocyclic compound, 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, molecular formula is C5H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4.2.6 3,3′,5,5′-Tetrakis[(4-brom-3,5-dimethyl-1H-pyrazol-1-yl)methyl]-2,2′,4,4′,6,6′-hexamethyldiphenylmethane (35) To a suspension of NaOH (192 mg, 4.81 mmol) in DMF (20 mL), 4-bromo-3,5-dimethyl-1H-pyrazole (841 mg, 4.81 mmol) (37) was added and stirred at room temperature for 20 min. After the addition of compound 20 (500 mg, 0.80 mmol) the reaction mixture was stirred for 72 h at room temperature. Afterwards, the mixture was poured into ice water (200 mL), the formed precipitate filtered off, washed thoroughly with distilled water and dried to constant mass in the desiccator. The desired compound 35 was obtained as a snow-white solid (750 mg, 94percent), mp 216 °C. 1H NMR (500 MHz, CDCl3): delta 5.17 (s, 8H), 4.18 (s, 2H), 2.19 (s, 6H), 2.12 (s, 12H), 2.05 (s, 12H), 2.01 (s, 12H) ppm. 13C NMR (CDCl3, 125 MHz): delta 145.52, 137.86, 137.12, 136.80, 135.81, 130.51, 94.17, 49.69, 33.36, 17.35, 16.53, 12.40, 10.35 ppm. MS (ESI): m/z 1000.8, 827.2, 681.0, 507.0, 333.0. Anal. Calcd for C43H52Br4N8: C, 51.62; H, 5.24; N, 11.20. Found: C, 51.39; H, 5.49; N, 11.38.
The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Koch, Niklas; Rosien, Jan-Ruven; Mazik, Monika; Tetrahedron; vol. 70; 45; (2014); p. 8758 – 8767;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics