Related Products of 49633-25-2,Some common heterocyclic compound, 49633-25-2, name is 3-Isopropylpyrazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of3-isopropyl-lH-pyrazole (3.74 g), 2- chloro-5-trifluoromethylpyridine (6.17 g) and N- methylpyrrolidone (18.7 ml) was addedNaOH (trademark: Tosoh pearl, 2.03 g) while stirring the mixture at room temperature. After reaction as it was for 9 hours, water (38 ml) and 6N hydrochloric acid (85 ml) were added, and the mixture was extracted with ethyl acetate. The extract was washed with water and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with hexane and then with toluene to give2- (3-isopropyl-lH-pyrazol-1-yl)-5- (trifluoromethyl) pyridine (6.94 g, yield 80%) as a colorless oil. H-NMR (CDC13)8 : 1.33 (6H, d, J=7.0 Hz), 3.0-3. 2(1H, m), 6.34(1H, d, J=2.5 Hz), 7.97(1H, dd, J=8.7, 2.1 Hz), 8.05(1H, d, J=8.7 Hz), 8.47(1H, d, J=2.5 Hz), 8.6-8. 7(1H, m).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Isopropylpyrazole, its application will become more common.
Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/99793; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics