Adding a certain compound to certain chemical reactions, such as: 930-36-9, name is 1-Methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 930-36-9, SDS of cas: 930-36-9
The N-methylpyrazole sulfonyl chloride was prepared by adding N- methylpyrazole to chilled (0C) chlorosulfonic acid. The reaction mixture was allowed to warm to room temperature and then heated to 100C overnight under a stream of N2. The reaction mixture was then cooled to room temperature and chilled to 0C. To this solution was added thionyl chloride (2.5 eq. ) and the reaction was stirred at room temperature for 30 min. , then warmed to 70C for two hours. The reaction was cooled to room temperature and then chilled in an ice bath. Water and ice were slowly added to the reaction mixture to precipitate a white solid which was collected by filtration. The desired sulfonyl chloride was washed with cold water and hexane.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methylpyrazole, and friends who are interested can also refer to it.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/97162; (2005); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics