Related Products of 35100-92-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35100-92-6 as follows.
6- (4 – ((2,5-dichloro-4-yl) amino) piperidin-1-yl) -3-cyano-pyridine (100mg, 0.286mmol) in n-butanol (5mL) solution of was added 1,5-dimethyl -1H- pyrazol-3-amine (40mg, 0.41mmol) and trifluoroacetic acid (212muL, 2.86mmol). The resultant reaction system was heated up to 120 deg.] C, sealed tube for 24 hours, until the reaction system was cooled to room temperature, concentrated under reduced pressure. To the resulting residue was added ethyl acetate (50 mL) was diluted and washed with water (15mL × 3) washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography Analysis (DCM / EtOAc / MeOH (v / v / v) = 25/5/1) to give the title compound as a whiteSolid (53mg, 44% yield)
According to the analysis of related databases, 35100-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
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