Application of 67-51-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
3,5-Dimethyl-1H-pyrazole, 78.5 g (0.818 mol), was dissolved in 700 mL of water heated to 70°C, and 517 g (3.271 mol) of potassium permanganate was added to the hot solution, maintaining the temperature no higher than 90°C. The mixture was cooled to room temperature, the precipitate of MnO2 was filtered off and washed with water, and the filtrate was acidified with aqueous HCl to pH 2 and left overnight. The precipitate was filtered off and washed with water. Yield 41.75 g (33percent), white crystals, mp 257?258°C. 1H NMR spectrum: delta 7.07 ppm, s (1H, 4-H). 5-Methyl-1H-pyrazole-3-carboxylic acid (2). The aqueous filtrate obtained after separation of diacid 1, was neutralized to pH 5?6, and the precipitate of 2 was filtered off and washed with water. Yield 18.1 g (18percent), white crystals, mp 210?211°C. 1H NMR spectrum, delta, ppm: 2.25 s (3H, CH3), 6.42 s (1H, 4-H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kharaneko; Russian Journal of Organic Chemistry; vol. 52; 9; (2016); p. 1322 – 1325; Zh. Org. Khim.; vol. 52; 9; (2016); p. 1334 – 1337,4;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics