Adding a certain compound to certain chemical reactions, such as: 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35691-93-1, HPLC of Formula: C8H12N2O2
3,5-Dimethyl-1H-pyrazole-carboxylic acid ethyl ester(0.83 g, 5 mM), potassium carbonate (2.07 g, 15 mM), tetrabutylammonium bromide(0.11 g, 0.25 mM), and ethyl bromoacetate (3.32 mL, 5 mM) were mixed in 1,4-dioxane(60 mL). The reaction mixture was stirred at 140 C for 24 h and the solvent was removedby evaporation. The residue was dissolved in CH2Cl2 (40 mL) and washed with deionized water (200 mL). The organic layer was dried over MgSO4 and evaporated to give 1-ethoxycarbonylmethyl-3,5dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester (Ecmdpcaee) as afaint yellow oil. Yield: 0.78 g (78.7%). 1H NMR (CDCl3, 500 MHz) delta: 4.80 (s, 2H), 4.16(q, 2H), 4.24 (q, 2H), 2.47 (s, 3H), 2.42 (s, 3H), 1.36 (t, 3H), 1.28 (t, 3H); ESI-MS: m/z(%) 254.95 [MH+] (100%), 274.10[MK+] (100%); IR (cm-1, KBr pellet): 3378 (m), 2985 (vs), 2931 (vs), 2587 (w), 1735 (vs), 1702 (s), 1656 (w), 1552 (s), 1447 (m), 1374 (s), 1356 (w), 1282 (s), 1233 (vs), 1160 (w), 1051 (w), 873 (m), 686 (m); m.p.: 50-52 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xia, Qinghong; Ren, Yanqiu; Cheng, Mei-Ling; Liu, Xiuxiu; Chen, Sheng; Zhai, Changwei; Liu, Qi; Journal of Coordination Chemistry; vol. 68; 10; (2015); p. 1688 – 1704;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics