In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 179692-08-1, name is Ethyl 4-iodo-1H-pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 179692-08-1
Intermediate 28 (1-28) Ethyl 2-[ 1 -[(tert-butoxycarbonylamino)methyl]-2-[tert-butyl(dimethyl)silyl]oxy-ethyl]- 4-iodo-pyrazole-3-carboxyla Di-tert-butyl azodicarboxylate (1.97 g, 8.53 mmol) was added to a stirred solution of 4- iodo-lH-pyrazole-3-carboxylic acid ethyl ester (1.26 g, 4.74 mmol), [3-(tert- butyldimethylsilanyloxy)-2-hydroxypropyl]carbamic acid tert- vXy ester (2.90 g, 9.48 mmol) and triphenylphosphine (2.24 g, 8.53 mmol) in THF (23.6 mL) under nitrogen atmosphere. The mixture was stirred at rt for 2.5 h. The solvent was evaporated and the residue was treated with DIPE. The solid (Ph3PO) was filtered off and the filtrate was evaporated in vacuo. The crude product was purified by flash column chromatography (silica; DCM in Heptane 50/50 to 100/0 then EtOAc in DCM 0/100 to 3/97). The desired fractions were collected and concentrated in vacuo to yield intermediate compound 1-28 (2.57 g, 98%) as a colorless oil.
The synthetic route of 179692-08-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALONSO-DE DIEGO, Sergio-Alvar; CID-NUNEZ, Jose, Maria; DELGADO-GONZALEZ, Oscar; DECORTE, Annelies, Marie, Antonius; MACDONALD, Gregor, James; MEGENS, Antonius, Adrianus, Hendrikus, Petrus; TRABANCO-SUAREZ, Andres, Avelino; GARCIA-MOLINA, Aranzazu; ANDRES-GIL, Jose, Ignacio; WO2014/195311; (2014); A1;,
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