Reference of 299930-70-4, A common heterocyclic compound, 299930-70-4, name is 3-Chloro-1-methyl-4-nitro-1H-pyrazole, molecular formula is C4H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: Into a 100 mL round bottom flask containing a solution of 3-chloro-l-methyl-4-nitro- lH-pyrazole (2.0 g) in ethyl acetate (50 mL) was added Raney Ni (1.0 g) and the reaction mixture was stirred under hydrogen atmosphere for 24 h. The reaction mixture was filtered through celite and washed with ethyl acetate. The filtrate was concentrated under reduced pressure and purified by flash chromatography eluting with ethyl acetate in petroleum ether (40- 50%) to afford 3 -chloro-1 -methyl-1H-pyrazol-4-amine as an oil. *H NMR (CD3OD, 400 MHz): 5 7.17 (s, 1H), 3.73 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; GIBEAU, Craig, R.; (84 pag.)WO2016/144849; (2016); A1;,
Pyrazole – Wikipedia,
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