Application of 181585-93-3,Some common heterocyclic compound, 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, molecular formula is C5H5N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) 5-Nitro-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester A mixture of methyl-3-nitro-1-H-pyrazole-5-carboxylate (ART-CHEM) (600 mg, 3.5 mmol), 3,4,5-trifluoromethylbenzyl bromide (789 mg, 3.5 mmol) and cesium carbonate (1.37 g, 4.2 mmol) in 15 ml of acetonitrile was stirred at 60 C. for 2 hours. The reaction mixture was concentrated, hydrolyzed and extracted with ethyl acetate. The organic phase was dried, evaporated and the residue triturated with diethyl ether to yield the title compound as a colorless solid (698 mg, Yield=63%). MS ISP (m/e): 333.1 (100) [(M+NH4)+]. 1H NMR (CDCl3, 300 MHz): delta (ppm)=7.43 (s, 1H), 7.04 (t, 2H), 5.75 (s, 2H), 3.95 (s, 3H).
The synthetic route of 181585-93-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Baumann, Karlheinz; Goetschi, Erwin; Jolidon, Synese; Limberg, Anja; Luebbers, Thomas; US2010/120874; (2010); A1;,
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