Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Amino-5-phenylpyrazole
A mixture of 2,6-Dichloro-4-(piperidine-l-sulfonyl)-pyridine (190 mg, 0.644 mmol), 3-amino-5-phenylpyrazole (113 mg, 0.708 mmol) and DIPEA (249 mg, 1.93 mmol) in anhydrous DMSO (2 mL) was heated at 140 C for 16h. The mixture was partitioned between EtOAc (50 mL) and water (15 mL) and the phases separated. The organic phase was washed with water (2 x 5 mL), brine (5 mL), dried (Na2S04), filtered and concentrated in vacuo. The crude material was purified by flash chromatography, eluting with EtOAc (50 %) in heptane + to afford the title compound as a brown solid (65 mg, 15%) MS: m/z = 418.1 (M+H) .
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1572-10-7.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BROMIDGE, Steven; BURCH, Jason; HEIFETZ, Alexander; KRULLE, Thomas; MONTALBETTI, Christian A.G.N.; PEI, Zhonghua; PEREZ-FUERTES, Yolanda; TRANI, Giancarlo; (223 pag.)WO2016/1341; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics