Application of 3398-16-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3398-16-1 name is 4-Bromo-3,5-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00406] To a mixture of 66-1 (1.0 g, 5.7 mmol, 1.00 eq) and K2C03 (1.6 g, 11.4 mmol, 2.00 eq) in DMF (10.0 mL), was added 66-2 (1.9 g, 11.4 mmol, 1.3 mL, 2.00 eq). The resulting mixture was stirred at 60 C for 3H. LCMS showed the reaction was complete. The mixture was diluted with EtOAc (40 mL), washed with water (40 mL *5). The combined organic layers were dried over anhydrous Na2S04, and concentrated under vacuum. 66-3 (1.5 g, crude) was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-3,5-dimethylpyrazole, and friends who are interested can also refer to it.
Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics