Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Compound 2 (15 mmol) and SOCl2 (30 mL) were added. The mixtures were heated to reflux at 80 &176;C for 3 hours. Residual SOCl2 was removed by vacuum distillation in order to obtain compound 3. Finally, the compounds 6 (10 mmol) dissolved in dichloromethane (20 mL) and triethylamine (5 mL) were added. The mixtures were cooled to 0 &176;C and compound 3 dissolved in dichloromethane (20 mL) were added dropwise under stirring at a temperature not exceeding 5 &176;C. The final mixtures were stirred at room temperature for 3 hours and the target compounds 1a-1p were purified via column chromatography.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 176969-34-9.
Reference:
Article; Zhang, Aigui; Zhou, Jingya; Tao, Ke; Hou, Taiping; Jin, Hong; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3042 – 3045;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics