Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28466-26-4, name is 4-Aminopyrazole, A new synthetic method of this compound is introduced below., Formula: C3H5N3
3.0 g of 4-amino-1H-pyrazole (2) was dissolved in a 7.5 g / 160 mL NaHCO3 / tetrahydrofuran mixed solution, 8.6 g of di-tert-butyl dicarbonate was added and reacted at room temperature for 2 days. The solvent was evaporated to dryness on a rotary evaporator, and then dissolved with ethyl acetate, and washed three times with water, aqueous citric acid, and saturated sodium chloride solution; The organic phase was dried over anhydrous magnesium sulfate over night and filtered and evaporated After the crude product was washed with n-hexane, a pure 5.0 g of a pink solid 3 was obtained in a yield of 75%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shandong University; Zhang Yingjie; Liang Xuewu; Xu Wenfang; (47 pag.)CN108864057; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics