In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-69-0, name is 4-Iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Iodopyrazole
Under an atmosphere of nitrogen a solution of 4-iodo-1H-pyrazole (1.58 g; 8.0 mmol) in anhyd. THF wasadded dropwise to a freshly prepared suspension of sodium hydride (0.21 g; 8.7 mmol). The reactionmixture was stirred for 3 h and then 1.0 mL of methyl iodide (2.24 g; 15.8 mmol) was added dropwise.The mixture was stirred for additional 12 h and quenched by adding approximately 50 mL of water. Thecrude product was extracted with Et2O and dried over sodium sulfate. After evaporation of the solvent theproduct was obtained as a yellowish solid. Yield: 1.64 g (98%)
The synthetic route of 3469-69-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ahlburg, Nils Lennart; Doppleb, Olivia; Hillrichs, Kai; Namyslo, Jan C.; Huebner, Eike G.; Schmidt, Andreas; Heterocycles; vol. 96; 7; (2018); p. 1203 – 1215;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics