Reference of 31108-57-3, The chemical industry reduces the impact on the environment during synthesis 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, I believe this compound will play a more active role in future production and life.
To a solution of II-H18 (150 mg, 0.39 mmol) in acetone (3 mL) were added lH-pyrazole-4- carbonitrilev (43.6 mg, 0.47 mmol) and K2CO3(l08 mg, 0.78 mmol). After stirring at 25C for 14 h, the mixture was diluted with water (20 mL) and extracted with EtOAc (2 x 30 mL). The organic solution was separated, dried over Na2S04, filtered and concentrated. The residue was purified by flash column (20-50% of EtOAc in PE) to give II-H19 (76 mg) as a solid. The solid was further purified by HPLC separation (column: Xtimate C18 (2903) l50*25mm*5um, gradient: 67-87% B (water(0.225%FA)-ACN), flow rate: 25 mL/min) to give II-H19 (43 mg) as a solid. (2904) 1H NMR (400 MHz, CDC13) dH 7.86 (s, 1 H), 7.81 (s, 1 H), 5.05-4.84 (m, 2 H), 2.66-2.57 (m, 1 H), 2.30-2.13 (m, 1 H), 2.10-2.05 (m, 1 H), 1.90-1.95 (m, 7H), 1.53-1.40 (m, 3H), 1.36- 1.22 (m, 8 H), 1.14 – 0.80 (m, 4 H), 0.82 – 0.72 (m, 1 H), 0.68 (s, 3 H); LC-ELSDE/MS purity 99%, MS ESI calcd. for C24H33N302 [M+H]+396.2, found 396.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SAGE THERAPEUTICS, INC.; ROBICHAUD, Albert, Jean; SALITURO, Francesco, G.; BLANCO-PILLADO, Maria, Jesus; LA, Daniel; HARRISON, Boyd, L.; (646 pag.)WO2019/126761; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics