Application of 1192-21-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1192-21-8 name is 1-Methyl-1H-pyrazol-5-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To the solution containing the amine compound (A-1), 700 mL of methanol was added. While stirring the obtained solution at an internal temperature of 5 ° C., To this solution, 120 g of an 85percent by mass aqueous solution of phosphoric acid (H 3 PO 4) (1.0 mol as H 3 PO 4) was added dropwise. By dropwise addition, Crystals precipitated. Precipitated crystals were collected by filtration, 111 g of crystals (slightly yellow to white crystals) of the organic amine salt (I-beta-2) were obtained (yield 57percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.
Reference:
Patent; FUJIFILM Corporation; Mikoshiba, Atsushi; (36 pag.)JP2017/19914; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics