Electric Literature of 27006-76-4, The chemical industry reduces the impact on the environment during synthesis 27006-76-4, name is 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, I believe this compound will play a more active role in future production and life.
General procedure: Toa stirred solution of substituted phenol (75 mmol) in DMF or DMSO (25mL), wasadded solid potassium hydroxide (90 mmol) at room temperature. The resultingmixture was stirred at 45 Cfor 2 h and then 5-chloropyrazole-4-carbaldehyde (5) (50 mmol) was added in portions. The reaction mixture was heatedto 110C. After6-22 h, the mixture was poured into water and extracted with ethyl acetate. Thecombined extracts were dried over anhydrous magnesium sulfate, filtered, andconcentrated to obtain compounds 6a-6z. Then the product 6 (10mmol) was added into a stirred mixture of hydroxylamine hydrochloride(15 mmol) and potassium hydroxide (20 mmol) in methanol or ethanol (30 mL) atthe room temperature. The reaction mixture was refluxed for 5-20 h. Oncompletion, the mixture was poured into water (80 mL), and the solidprecipitate was filtered, washed with water, and dried to afford thecorresponding pyrazole oximes 7a-7z, which were used for the following transformations withoutfurther purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dai, Hong; Li, Gang; Chen, Jia; Shi, Yujun; Ge, Shushan; Fan, Chongguang; He, Haibing; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3818 – 3821;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics