Some scientific research about C12H13N3O2

Reference of 16078-71-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

[00139] A solution of 1 ,2-bis-(4-chloro-phenyl)-ethanone (lOOmg, 0.38 mmol) in dichloroethane (1 mL) is stirred at room temperature while TiCl4 (143 mg, 0.75 mmol) is added in dropwise. After the addition, the mixture is stirred at room temperature for 5 min and a solution of 5-amino-l-phenyl-lH-pyrazole-4-carboxilic acid ethyl ester (97 mg, 0.42 mmol) in dichloroethane (1 mL) is added dropwise. After the addition, the EPO mixture is heated to 125 0C for 5 h. After cooling down the mixture, it is poured into a mixture of ice cold saturated aqueous NaHCO3 solution (15 mL) and EtOAc (15 mL). The resulted mixture is filtered through celite to remove the precipitate and washed with EtOAc (2×5 mL). The filtrate is extracted by EtOAc (3*5 mL). The organic layers are combined and washed with brine and dried (MgSO4). After filtering off the drying agent, the filtrate is concentrated and purified by preparative LC/MS to provide the titled compound 5,6-bis-(4-chloro-phenyl)-l-phenyl-lH-pyrazolo[3,4-b]pyridin-4-ol as light yellow solid.(55 mg, 31%). 1H NMR (MeOD) delta(ppm) 8.37(s, IH), 8.23 (d, 2H), 7.53 (t, 2H), 7.34(t, IH), 7.31 (d, 2H), 7.29 (d, 2H), 7.23 (d, 2H), 7.15 (d, 2H); HPLC-MS calculated for C24H15Ci2N3O (M+l+): 432.1, found: 432.2.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IRM LLC; WO2006/47516; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics