26621-44-3, name is 3-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C3H3N3O2
Referential Example 8 5-(Oxetan-3-yl)-lH-pyrazol-3-amine (91) step 1 : Into a 3 L 4-necked round-bottom flask under nitrogen was placed a solution of 3-nitro-lH- pyrazole (100 g, 884.37 mmol, 1.00 equiv.) in THF (1.5 L), followed by the addition of NaH (53 g, 1.32 mol, 1.50 equiv, 60%> suspension) batchwise at 0C. The resulting solution was stirred at 0 C for 1 h. A solution of [2-(chloromethoxy)ethyl]trimethylsilane (1 17.4 g, 704.17 mmol, 1.20 equiv) in THF (500 mL) was then added dropwise with stirring at 0 C. The resulting solution was stirred at 25 C for 1 h, quenched by the addition of EtOH (200 mL), concentrated under vacuum and diluted with 2 L of EtOAc. The resulting mixture was washed with 2×1 L of brine, dried (Na2S04) and concentrated in vacuo. The residue was triturated with 200 mL of petroleum ether. The solids were collected by filtration and washed with petroleum ether (2 x 500 mL) to afford 125 g (52%) of 3-nitro-l -[[2- (trimethylsilyl)ethoxy]methyl]-lH-pyrazole as a yellow solid.
The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Pyrazole – Wikipedia,
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