Related Products of 139756-02-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-02-8 as follows.
Synthesis of Ba; Step 7. 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (1 eq) and 3-Bromo-4-methoxybenzaldehyde (1.1 eq) were suspended in ethanol 5 ml and the mixture heated at 70 C for 2 hours after conformation of forming of imine by TLC. Added CuC12 (3 eq) and the reaction mixture heated at 75 C under 02 for 3 hours. After completion of the reaction, the ethanol was removed under vacuum. Then workupwith ethyl acetate and water. Separate the organic layer and Water layer re-extracted with 2×25 ml ethyl acetate. The combined organic layers are washed with brine solution, concentrated under vacuum. The residue was purified by column chromatography on silica the desired product Ba as a white solid; yield 85%. 1H NMR (400 MHz DMSO): 8.31(d J = 2.0Hz 1H),8.29(s 1H),8.14(dd J = 8.8,2.0Hz1H),7.24(dJ= 8.8Hz) 4.14(s 3H),3.93(s 3H)2.8(tJ 7.3Hz 2H),1.76(m 2H),0.95(tJ=7.3Hz 3H). MASS: ESI [M+2 + H] + 377.05; Elemental anal. calcd. for C16H17BrN4O2C, 50.94; H, 4.54; Br, 21.18; N, 14.85; 0, 8.48; found C, 50.89; H, 4.56; Br, 21.21; N,14.83; 0, 8.50.
According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; SAWANT, Sanghapal Damodar; GINNEREDDY, Lakshma Reddy; MAHESUNI, Srinivas; SYED, Sajad Hussain; DAR, Mohd Ishaq; NARGOTRA, Amit; MAHAJAN, Priya; VISHWAKARMA, Ram Asrey; WO2015/114647; (2015); A1;,
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