Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-pyrazol-5-amine
(3 S)-7-(2-Chloro-5 -methylpyrimidin-4-yl)-3 -methyl-2-((3 -methylpyrazin-2-yl)methyl)-3 ,4-dihydropyrrolo [1 ,2-a]pyrazin- 1 (2H)-one (125 mg, 0.33 mmol), 1-methyl-i H-pyrazol5-amine (34.9 mg, 0.36 mmol), cesium carbonate (213 mg, 0.65 mmol) and BrettPhos 3rdgeneration pre-catalyst (14.80 mg, 0.02 mmol) were suspended in tert-butanol (5 mL) andde-gassed for 10 minutes. The reaction was heated to 80 °C for 18 hours under nitrogen.The mixture was cooled to room temperature, diluted with EtOAc (50 mL), washed with saturated aqueous sodium bicarbonate (10 mL) and the layers separated. The aqueous portion was washed with ethyl acetate (50 mL) and the combined organics were dried (sodium sulfate) and concentrated in vacuo to a brown gum which was taken up in DMSO(5 mL) and filtered. The crude product was purified by preparative HPLC (Waters XBridge Prep Ci8 OBD column, Sji silica, 30 mm diameter, 100 mm length), using decreasingly polar mixtures of water (containing 1percent NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford (3S)-3-methyl-7-(5-methyl-2- ((i-methyl-i H-pyrazol-5 -yl)amino)pyrimidin-4-yl)-2-((3 -methylpyrazin-2-yl)methyl)-3 ,4-dihydropyrrolo[i,2-a]pyrazin-i(2H)-one (97 mg, 67.0 percent) as a white solid. ?H NMR(500 MHz, DMSO, 30 °C) 1.43 (3H, d), 2.58 – 2.6 (3H, m), 2.83 (3H, s), 3.94 (3H, s), 4.15- 4.25 (iH, m), 4.44 (iH, dd), 4.55 – 4.67 (2H, m), 5.60 (iH, d), 6.52 (iH, d), 7.50 (iH, d),7.59 (iH, d), 7.90 (iH, d), 8.49 (iH, d), 8.64 – 8.71 (2H, m), 9.33 (iH, s). mlz: ES+[M+H]+ 443.
According to the analysis of related databases, 1192-21-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
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