These common heterocyclic compound, 15878-00-9, name is 4-Chloro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Chloro-1H-pyrazole
EXAMPLE 5 7.65 g (0.075 mole) of 4-chloropyrazole were suspended in 100 ml of water and the suspension obtained first had added to it 72 g (0.64 mole) of a 50% strength aqueous KOH solution and then at 0 C. 17 g (0.15 mole) of a 30% strength aqueous hydrogen peroxide solution. After the reaction mixture had been stirred for 5 minutes, 28 g (0.18 mole) of phthalic anhydride were added in small portions at 10 C., and the whole was stirred overnight and then worked up similarly to Example 1. Yield: 7.1 g of 4-chloro-N-hydroxypyrazole, corresponding to 80% of theory.
The synthetic route of 4-Chloro-1H-pyrazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Basf Aktiengesellschaft; US4945167; (1990); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics