Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H4N2O
To a stirred solution of (l-phenylazetidin-3-yl) methanesuifonate (500 mg, 2.20 mmol) and lH-pyrazole-4- carbaidehyde (317 08 mg, 3.30 mmol) in DMF (10 mL) was added cesium carbonate (1.43 g, 4.40 mmol) anf the reaction mixture was heated to 80 C for 16 hours. After consumption of starting material, the reaction mass was diluted with water, extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulphate and evaporated under reduced pressure. The crude was purified by combi-flash column chromatography (using 30% ethyl acetate in n-hexane) to afford l-(l-phenyl-azetidin-3-yl)-lH-pyrazole-4-carbaldehyde (300 mg, 1.23 mmol, 55 80% yield, 93% purity, 000) as light yellow solid. LCMS (ES+) = 227 8 | M I f )
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35344-95-7.
Reference:
Patent; C4 THERAPEUTICS, INC.; VEITS, Gesine, Kerstin; HE, Minsheng; HENDERSON, James, A.; NASVESCHUK, Christopher, G.; PHILLIPS, Andrew, J.; GOOD, Andrew, Charles; (471 pag.)WO2019/191112; (2019); A1;,
Pyrazole – Wikipedia,
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