In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Ethyl 5-amino-1H-pyrazole-3-carboxylate
Subsequently, to a solution of ethyl 5-amino-3-pyrazolecarboxylate (1.337 g) in tetrahydrofuran (15 mL) was added pyridine (1.385 mL), and then a solution of 4,5-difluoro-2-methyl-benzoyl chloride in tetrahydrofuran (2 mL) was added dropwise with ice cooling. After stirring overnight at room temperature, ethanol (5 mL) and water (45 mL) were added to the reaction mixture, and the precipitated solid was collected by filtration to obtain the title compound (2.271 g) as a white solid.
The synthetic route of 105434-90-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JAPAN TOBACCO, INC.; US2009/36450; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics