Related Products of 34334-96-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34334-96-8, name is 3-Methyl-5-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Add acetonitrile (75 rnL) to a mixture of (2.0 g, 15rnmoi). potassium carbonate (4.1 g, 2.0 eq), and 1-chioro-2-propanol (3.8 mL, 3.0 eq).Stir at 85 C overnight. Cool to rt. Filter and rinse the solids with EtOAc. Concentrate the filtrate in vacuo to provide a residue. Subject the residue to normal phase chromatography, eluting with 50% EtOAc in hexanes, to give the title compound (2.0 g, 65%). MS (ES) ,n/z 186 (M+1-1).
The synthetic route of 3-Methyl-5-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; BASTIAN, Jolie Anne; CLAYTON, Joshua Ryan; COATES, David Andrew; SALL, Daniel Jon; WOODS, Timothy Andrew; (58 pag.)WO2018/13486; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics