In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 28466-26-4 as follows. category: pyrazoles-derivatives
General procedure: 3 -Phenyl- lH-pyrazol-4-amine (100.0 mg, 0.6 mmol, 1.0 equiv) was dissolved in THF (15.0 mL). TEA (l27. l mg, 1.3 mmol, 2.0 equiv) and l-butyl-4-isocyanatobenzene (132.1 mg, 0.8 mmol, 1.2 equiv) were added dropwise. The solution was then stirred for 2 hours at RT. The resulting solution was concentrated under vacuum. The crude product was purified by Prep-HPLC with the following conditions: Column: XBridge Prep OBD C18 Column, 30x l50mm 5um; Mobile Phase A:Water (10 MMOL/L NH4HCO3), Mobile Phase B:ACN; Flow rate:60 mL/min; Gradient:50% B to 82% B in 7.5 min; UV 254/210 nm; RTl :4.48. l-(4-Butylphenyl)-3-(3-phenyl-lH-pyrazol-4-yl)urea (30 mg, 14.3%) was isolated as a white solid. LCMS Method G, MS-ESI: 335. l[M+H+]
According to the analysis of related databases, 28466-26-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IFM DUE, INC.; ROUSH, William R.; VENKATRAMAN, Shankar; GLICK, Gary; SEIDEL, Hans Martin; (171 pag.)WO2020/10155; (2020); A1;,
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