Adding a certain compound to certain chemical reactions, such as: 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 948570-75-0, HPLC of Formula: C6H9N3O3
A par flask was charged with 1-(2-Methoxy-ethyl)-4-nitro-1H-pyrazole 16 (2.5 g, 14.60 mmol) in EtOH (250 mL) followed by addition of Pd-C (20% w/w, 0.50 g). The flask was evacuated under vacuum and then purged with hydrogen. The reaction was stirred under hydrogen atmosphere (1 atm) for 1 6h. After the completion of reaction, the solution was filtered through sintered funnel with a pad of celite, washed with methanol and concentrated under reduced pressure to afford precursor-06 (2.0 g, 97% yield) that was taken as such for the next step without any further purification. ?H NMR (400 MHz,CDC13): 6 7.03 (s, 1H), 6.89 (s, 1H), 4.19-4.17 (t, 2H), 3.78 (br s, 2H), 3.67-3.64 (t, 2H), 3.21 (s, 3H). MS: 142.11 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JUBILANT BIOSYS LIMITED; VENKATESHAPPA, Chandregowda; SIVANANDHAN, Dhanalakshmi; BAKTHAVATCHALAM, Rajagopal; KETHIRI, Raghava Reddy; VISWANADHAN, Vellarkad Narayana; GIRI, Sanjeev; WO2015/25197; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics