Adding a certain compound to certain chemical reactions, such as: 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 132712-71-1, Formula: C4H6N2O
General procedure: To a neat solution containing 11H-indeno[1,2-b]quinoxalin-11-one (1 mmol), pyrazolone (1 mmol), and malononitrile (1 mmol), 10% mol of Na2CO3 in ethanol(10 mL) was added. The reaction mixture was heated at 70 8C for 12 h. After completion of the reaction as indicated by TLC, the precipitate was filtrated and washed with cold ethanol to afford the pure product 8. 4.6 6′-amino-3′, 7-dimethyl-1’H-spiro [indeno[1,2-b]quinoxaline-11′,4-pyrano[2,3-c] pyrazole] carbonitrile (8b) Light brown powder (0.35 g, yield 90%). Mp 258-262 C. IR (KBr) 3445, 3250, 3224, 2966, 3110, 2193, 1638, 1597, 1447, 1398. 1H NMR (250 MHz, DMSO-d6): deltaH (ppm) 1.13 (3H, s, CH3), 2.58 (3H, s, CH3-Ar), 7.32-8.14 (9H, m, H-Ar and NH2), 12.6 (1H, s, NH). 13C NMR (62 MHz, DMSO-d6): deltaC (ppm) 8.9 (CH3), 21.1 (CH3-Ar), 56.5 (C-Spiro), 96.3 (C-CN), 118.7 (CN), 121.4, 125.6, 127.8, 128.6, 129.4, 131.5, 132.7, 135.6, 139.7, 140.4, 142.0, 150.8, 152.6, 155.0, 162.4 (C-Ar and C-Pyrazole), 163.3 (C-NH2). Anal. calcd for C23H16N6O: C, 70.40; H, 4.11; N, 21.42. Found: C, 70.44; H, 4.14; N, 21.39.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1H-pyrazol-5-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Soleimani, Ebrahim; Hariri, Mina; Saei, Parisa; Comptes Rendus Chimie; vol. 16; 9; (2013); p. 773 – 777;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics