Related Products of 158001-28-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 158001-28-6 as follows.
In a 100mL round-bottomed flask, add 1-tert-butyl-5-amino-1H-pyrazole-4-carbonitrile (5g, 30.47mmol), 80mL formamide solution, and heat the mixture in an oil bath to 180 C. After about 5 h, the reaction was monitored by TLC (developer: PE / EtOAc = 1: 1). After the reaction solution was cooled, 50 mL of water and CH 2 Cl 2 (200 mL × 3) were added for extraction. The organic phases were combined, dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography (eluent: PE / EtOAc = 4/1). -1/1) gave the product 1-tert-butyl-4-amino-1H-pyrazolo [3,4-d] pyrimidine as a white solid, 5.82 g, yield: 91%.
According to the analysis of related databases, 158001-28-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan University Huaxi Hospital; Chengdu Huaxi Jingzhun Medical Industrial Technology Institute Co., Ltd.; He Yang; Li Weimin; Shen Zhen; Chen Hai; Huang Ridong; Luo Yujiao; Zhou Xinglong; Chai Yingying; (26 pag.)CN110526921; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics