Application of 27258-33-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27258-33-9 as follows.
To a solution of 1 -methyl- lH-pyrazole-5-carbaldehyde (1.0 g, 9.09 mmol) in DMF (8 mL) was slowly added NBS (1.62 g, 9.09 mmol) in DMF (5 mL). The mixture was stirred for overnight at room temperature. 1 N NaOH (9.1 mL) was added and the solution was stirred for 10 min, diluted with water (100 mL), extracted with EtOAc (30 mL* 3), dried over MgS04, filtered and concentrated to afford an orange solid (1.57 g, 92%). LRMS m/z (M+H) 187.9 found, 188.0 required.
According to the analysis of related databases, 27258-33-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.; WO2014/81619; (2014); A1;,
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