Adding a certain compound to certain chemical reactions, such as: 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35100-92-6, category: pyrazoles-derivatives
To an orange, homogeneous solution of methyl 2-oxo-2H-pyran-3-carboxylate (1.9201 g, 12.46 mmol) in DMF (12.44 ml) under nitrogen at 0 C was added 1,5- dimethyl-1H-pyrazol-3-amine (1.3 822 g, 12.44 mmol).. After 6 h, the cold bath wasremoved, and the reaction was stirred to room temperature for 15 mm EDCI (1-(3-dimethylaminopropyl) ethyl carbodiimide) (3.10 g, 16.17 mmol) and DMAP (0.380 g,3.11 mmol) were added. After stirring overnight, the reaction was diluted with EtOAc(200 mL) and water (50 mL). The layers were separated, and the organic layer waswashed with water (50 mL) and brine (50 mL), dried over Na2SO4, filtered andconcentrated in vacuo to give a residue which was purified by flash chromatographyusing an ISCO 330g column (solid loading) eluting with 10-100% EtOAc/hex. Appropriate fractions were collected and concentrated in vacuo to give methyl 1-(1,5- dimethyl- 1 H-pyrazol-3 -yl)-2-oxo- 1 ,2-dihydropyridine-3 -carboxylate (0.8397 g, 3.40 mmol, 27.3 % yield) as a light orange solid.
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics