Adding a certain compound to certain chemical reactions, such as: 75092-30-7, name is 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75092-30-7, Safety of 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid
A round-bottom flash was charged with 4-iodo-i -methyl-i H-pyrazole-5-carboxylic acid(297 g, i.i8 mol), DCM (2.97 L), and i,i?-carbonyldiimidazole (CDI) (207 g, 97% bymass, 1.24 mol). The reaction mixture was stirred at room temperature for 45 mm.Ammonium chloride (189 g, 3.53 mol) and triethylamine (498 mL, 3.53 mol) were addedand the reaction mixture was stirred at room temperature overnight. The reaction mixturewas concentrated in vacuo and the residue was suspended in H20 (-3 L) and granulated at room temperature for 1 h. The solid was collected via filtration, washed with H20, and dried in a vacuum oven to afford 4-iodo-i -methyl-i H-pyrazole-5-carboxamide as a colorless solid (222 g, 75% yield).1H NMR (CDCI3) O: 7.53 (5, 1 H), 6.56 (br s, 1 H), 6.01 (br s, 1 H), 4.21 (5, 3H). UPLC (UPLC-MS Method 1): tR = 0.15 mm.MS (ES+): 251.1 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; DAROUT, Etzer; MCCLURE, Kim F.; PIOTROWSKI, David; RAYMER, Brian; (120 pag.)WO2016/55901; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics